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Research Paper | Genetics Science | Bulgaria | Volume 5 Issue 3, March 2016

Synchronization of Quadratically Damped Mathieu ? Duffing Based Chaotic Circuits with Applications to Secure Communications

Karayasheva D. ^[2] | Glushkova M. | Kadiyska T. | Boteva E.

Abstract: It is well known that various risk factors contribute to dental caries development and progression. Recent genome-wide association studies (GWAS) have led to the identification of gene locis associated with the risk of dental caries development and progression. GLUT2 is a member of the glucose transporter proteins, which has been associated with a higher habitual consumption of sugar and is a good potential candidate for caries development. For determination of GLUT2 gene polymorphism (rs5400, Thr110Ile) and its relation to dental caries susceptibility, an association clinical study of 108 Bulgarian volunteers, students in Sofia Medical University was performed. The participants completed a questionnaire about their dietary habits, snacks between meals, and BMI. Based on their DMFT (decayed, missing, filled teeth) scores, they were classified into three groups caries free (CF, DMFT=0), low caries experience (LCE, DMFT5) and high caries experience (HCE, DMFT9). DNA analysis was performed with a polymerase chain reaction (PCR) and direct sequencing. The data was processed by using IBM SPSS Statistics v19. Significant differences for the allele and genotype frequencies were not found between the three DMFT groups (CF, LCE and HCE). The Ile allele carriers had higher BMI (23, 4 vs 22, 3) and were more frequently snacking between meals (74 % vs 63, 5 %). From the results can be concluded that the GLUT2 receptor gene is likely to be associated with dental caries development in older Bulgarian population. It can be related to the individuals BMI and dietary habits.

Keywords: genetic factors, candidate genes, dental caries, GLUT-2, BMI

Edition: Volume 5 Issue 3, March 2016,

Pages: 83 - 86

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