Genotoxicity Screening of the Crude Ethanolic Extract of Artocarpus heterophyllus (langka) Unripe Fruit Using Allium cepa (Onion) Assay
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


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Research Paper | Biological Sciences | Philippines | Volume 7 Issue 5, May 2018 | Popularity: 6.9 / 10


     

Genotoxicity Screening of the Crude Ethanolic Extract of Artocarpus heterophyllus (langka) Unripe Fruit Using Allium cepa (Onion) Assay

Ma. Socorro G. Leong-on


Abstract: The crude ethanolic extract of Artocarpus heterophyllus (langka) unripe fruit was found out to lower blood sugar in alloxan-induced hyperglycemic white mice (Mus musculus). This study was conducted to determine the genotoxicity (mitotic index (MI) and percent chromosomal aberration ( %CA) of the crude ethanolic extract of A. heterophyllus unripe fruit using A. cepa (onion) assay. Onions with 1.5-2.0cm length of the roots were grown in different concentrations of A. heterophyllus extract. The 3 roots with a length of 2mm from the tips were harvested and fixed. Squash preparations were made for each of the concentration, positive and negative control in 3 replicates and 3 trials. Results showed that 15mg (MI=0.782+0.022, %CA=0.06+0.003) and 20mg (MI= 0.754+0.017, %CA=0.04+0.019) of the crude ethanolic extract per ml of ml of distilled water did not show genotoxicity based on the mitotic index (MI) and %chromosomal aberration (CA). They were comparable to the negative control used (dist. water) (MI=0.756+0.028, CA=0.08+0.022) (P


Keywords: genotoxicity, Artocarpus heterophyllus, Allium cepa assay, mitotic index


Edition: Volume 7 Issue 5, May 2018


Pages: 388 - 397



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Ma. Socorro G. Leong-on, "Genotoxicity Screening of the Crude Ethanolic Extract of Artocarpus heterophyllus (langka) Unripe Fruit Using Allium cepa (Onion) Assay", International Journal of Science and Research (IJSR), Volume 7 Issue 5, May 2018, pp. 388-397, https://www.ijsr.net/getabstract.php?paperid=ART20182180, DOI: https://www.doi.org/10.21275/ART20182180

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