International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


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Research Paper | Medicine Science | India | Volume 4 Issue 1, January 2015


Comparison of NS1 Antigen and Antibody Detection Method in Early Diagnosis of Dengue Infection

Neeti Mishra [3] | Shailendra Mohan Tripathi [4] | Vineeta Khare | Sana Islahi | Mohd Gulrez | Priyanka Shukla [4] | Shadma Yaqoob | Y. I. Singh


Abstract: Background and Aim The present study was carried out to evaluate whether NS-1 antigen help in early diagnosis of dengue infection as compared to Anti IgG/IgM antibody. Methodology For this purpose a total of 170 clinically suspect patients were enrolled in the study. All the patients were subjected to NS-1 Antigen and anti-IgG/IgM assessment using SD-Bioline Dengue Duo combination kit. Data was analyzed using SPSS version 15.0. Chi-square test, 't'-test, level of agreement (?) and sensitivity, specificity, positive predictive value, negative predictive value and accuracy of the results was calculated. Results Positivity rate was 53.5%. Maximum positivity was observed for NS-1 (n=74, 43.5%) followed by IgM (n=71, 41.8%). NS-1 antigen had a higher sensitivity rate for early detection (


Keywords: Dengue, Dengue infection, Early diagnosis, NS-1 Antigen, anti IgG/IgM


Edition: Volume 4 Issue 1, January 2015,


Pages: 2663 - 2668


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