Anticonvulsant Activity of the Decoction of Crossopteryx febrifuga in Mice

DJ Bassoueka, G. Taiwe Sotoing, G F Nsonde Ntandou, E. Ngo Bum

Abstract: The decoction of Crossopteryx febrifuga is evaluated for anticonvulsant activity in mice using strychnine (STR), picrotoxin (PIC), pentylenetetrazole (PTZ), maximal electroshock (MES) and isonicotinic hydrazid (INH) induced convulsions. A decoction of C. febrifuga at doses of 80 and 100 mg/kg protects 83.33 % of mice against STR-induced convulsions. At the dose of 120 mg / kg, it protects 100 % of mice against PIC-induced convulsions. On PTZ-induced convulsions, C. febrifuga decoction protects 66.67 % and 100 % of mice, respectively at doses of 120 and 100 mg / kg. While 66.67 % and 83.33 % of mice are protected against MES-induced convulsions respectively at the doses of 100 and 120 mg / kg. Moreover, it increased the latency time of convulsions induced by INH at the doses of 80, 100 and 120 mg / kg.

Keywords: Epilepsy, anticonvulsant, Crossopteryx febrifuga, mice, decoction