Synthesis and Biological Evaluation of a mutual Prodrug of Mafenide and Nalidixic Acid by Amino Acid Spacer

Enas Sami Ali, Ahlam J. Qasir

Abstract: The aim of this study has been to synthesize a useful drug, which may act with effectiveness both on the gram-positive and gram-negative bacteria (broad-spectrum). An amide-based mutual pro drugs were synthesized by coupling Mafenide acetate with Nalidixic acid by amino acid spacer (glycine or phenylalanine), and evaluated for in-vitro antibacterial activity with significant results.

Keywords: Nalidixic acid, Mafenide acetate, Pro drug, Antibacterial, glycine and phenylalanine

How to Cite?: Enas Sami Ali, Ahlam J. Qasir, "Synthesis and Biological Evaluation of a mutual Prodrug of Mafenide and Nalidixic Acid by Amino Acid Spacer", Volume 4 Issue 9, September 2015, International Journal of Science and Research (IJSR), Pages: 992-995, https://www.ijsr.net/getabstract.php?paperid=SUB158208, DOI: https://dx.doi.org/10.21275/SUB158208