International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


Downloads: 124 | Views: 212

Research Paper | Biology | India | Volume 4 Issue 9, September 2015


In Silico Sequence Analysis, Structure Prediction and Evaluation of Fatty Acid Synthase Protein (FAS) of Gallus gallus (Chicken) by Homology Modelling

Aman Singh Bhalla [2] | Roma Lal [2]


Abstract: FAS (Fatty acid synthase) an enzyme catalysing synthesis of fatty acid. The protein contains two subunits, namely A & B. Fatty acid synthase protein plays a key role in fat deposition in chicken as it was found that the protein is directly correlated with fat content of chicken. Administration of glucocorticoids changes the expression of FAS protein.3D structure of FAS protein was not available on RCSB Protein Databank. FAS protein of Human was available in the database which was selected as template for homology modelling. The present study deals with sequence analysis, secondary structure prediction and homology modelling of Fatty acid synthase of chicken. The secondary structure of protein shows that the protein is chiefly of -helical structure followed by coils and extended strand.3D structure of protein was predicted using SwissModel. The predicted structure was evaluated by Procheck, Errat, Ramachandran Plot, QMean, Z-Score using SAVES, an online structure evaluation server (http//services. mbi. ucla. edu/SAVES/).


Keywords: Fatty acid synthase, secondary structure, 3D structure, Homology modelling


Edition: Volume 4 Issue 9, September 2015,


Pages: 843 - 847


How to Download this Article?

Type Your Valid Email Address below to Receive the Article PDF Link


Verification Code will appear in 2 Seconds ... Wait

Top