International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


Downloads: 102 | Views: 180

Research Paper | Zoology | India | Volume 4 Issue 8, August 2015


66 kDa Protein Isolated from 24,000 g Fraction of Plasmodium berghei Exhibits Humoral Immune Response

Nisha Devi [4] | H. S. Banyal


Abstract: The various antigens involved in the induction of humoral immune response provide the opportunity for development of an effective malaria vaccine. In the present study, the immunogenicity and protective efficacy of 24, 000 g fraction was evaluated in rodent mouse model. A 66 kDa protein was eluted through immunoadsorption using 24, 000g fraction. The eluted protein was characterized by SDS-PAGE and mice immunized exhibited strong humoral immune response analysed by ELISA, IFA, DOT-ELISA and in vitro invasion inhibition assay. About fifty percent inhibition of parasite propagation was observed in vitro. This protein appears to be an important constituent of the parasite for antimalarial studies.


Keywords: Plasmodium berghei, malaria, 24, 000g fraction, 66 kDa protein


Edition: Volume 4 Issue 8, August 2015,


Pages: 1579 - 1583


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