Downloads: 105 | Views: 178

Comparative Studies | Chemistry | Egypt | Volume 4 Issue 8, August 2015

Facile Synthesis and Structural Characterization of Some Phthalazin-1(2H)-one Derivatives as Antimicrobial Nucleosides and Reactive Dye

M. A. EL-Hashash | S. A. Rizk | M. A. Kadhim

Abstract: A new series of 2, 4-disubstituted phthalazin-1 (2H) -one derivatives was synthesized via nucleophilic attach of N-2 of phthalazin-1 (2H) -one derivatives on different monosuccharides. Synthesis of phthalazinone nucleosides were very effective as antimicrobial. . Also the phthalazinone moiety can be used in synthesis of reactive nucleosides and dyes that was chemically bonded with proteins and fibers respectively as afforded highly stability of dyestuff wool and cotton textiles. The structure of the prepared compounds were elucidated by physical and spectral data like FT-IR, 1H-NMR and 13C-NMR

Keywords: phthalazin-1 2H one, allyl-, propargyl-phthalazinone, nucleosides, reactive dye

Edition: Volume 4 Issue 8, August 2015,

Pages: 1350 - 1358