International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064




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Comparative Studies | Chemistry | Egypt | Volume 4 Issue 8, August 2015 | Rating: 6.3 / 10


Facile Synthesis and Structural Characterization of Some Phthalazin-1(2H)-one Derivatives as Antimicrobial Nucleosides and Reactive Dye

M. A. EL-Hashash | S. A. Rizk | M. A. Kadhim


Abstract: A new series of 2, 4-disubstituted phthalazin-1 (2H) -one derivatives was synthesized via nucleophilic attach of N-2 of phthalazin-1 (2H) -one derivatives on different monosuccharides. Synthesis of phthalazinone nucleosides were very effective as antimicrobial. . Also the phthalazinone moiety can be used in synthesis of reactive nucleosides and dyes that was chemically bonded with proteins and fibers respectively as afforded highly stability of dyestuff wool and cotton textiles. The structure of the prepared compounds were elucidated by physical and spectral data like FT-IR, 1H-NMR and 13C-NMR


Keywords: phthalazin-1 2H one, allyl-, propargyl-phthalazinone, nucleosides, reactive dye


Edition: Volume 4 Issue 8, August 2015,


Pages: 1350 - 1358



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