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Research Paper | Hematology | India | Volume 4 Issue 8, August 2015
Coagulation Profiles in PIH ?a) To Determine Coagulation Index to Distinguish Severe Preeclampsia from Normal Pregnancy b) To Assess the Correlation of Coagulation Parameters in Normal Pregnancy & in Varying Grades of Preeclampsia
Abstract: Background PIH is the most common medical complication in pregnancy & it affects 2-10 % of all pregnancies. Thrombocytopenia is the most common finding which ocurrs in 11 % to 29 % of patients with PIH. It contributes significantly to maternal and perinatal morbidity and mortality. Methodology & Results The coagulation index in severe pre-eclampsia = 2.62 2.64. Higher the coagulation index severe is the pre-eclampsia. Thus the coagulation index of more than 1 can be safely taken as cut off value to distinguish between normal pregnancy & severe pre-eclampsia. In severe pre-eclampsia, the platelet count = (105 63.65) x 103/mm, PT = (19.6 5.7) sec, APTT = (78.7 22.7) sec & D dimer (0.48 0.07) was noted. Conclusion The degree of thrombocytopenia increases with severity of disease (lower the platelet count, greater are maternal and fetal morbidity and mortality. The coagulation parameters, especially Platelet count, aPTT and D- dimer can be safely used as an early indicator for the assessment of severity of PIH cases and can be used to monitor the progression of gestational hypertention to preeclampsia. So, it is concluded from this study that total platelet count with APTT & D dimer can be taken as an early and rapid procedure for screening preeclampsia cases at admission followed by serial platelet counts while monitoring coagulation indices.
Keywords: Pre-eclampsia, PIH, D-dimer, Platelet count, Multivariate, PT, APTT
Edition: Volume 4 Issue 8, August 2015,
Pages: 387 - 390