Antibacterial Activity of Some New Compounds of Sarcococcasaligna

Tahira Moeen Khan, Ismat Naeem

Abstract: Pharmacological studies of S. saligna revealed that the crude ethanolic extracts of S. saligna (aerial parts) and roots were cytotoxic and antibacterial but produced no platelet aggregation induced by ADP. Antibacterial activity of four alkaloids (compounds) was determined for the first time against 11 bacterial strains. Compound 1 (Sracosalgmine) showed moderate activity against Shigella boydii, Klebsiella pneumoniae. Compound 2 (Sracosalgminol) showed less activity with Staphylococuss aureus and Streptococus pyrogens. Compound 3 (sracosalgnenone) and Compound 4 (14-15 dehydrosarcovagine-D) were inactive against all bacterial strains

Keywords: Sarcococca saligna, Buxaceae, steroidal alkaloid, antibacterial alkaloid, Sracosalgmine, Sracosalgminol, Sracosalgnenone, 14-15 dehydrosarcovagine-D