Protective Effect of Aplotaxis Auriculata Root on Glycoprotein Components in Diethylnitrosamine (Den) Induced Hepatocellular Carcinoma in Rat

Abdul Aseeb CP, Mariappan V, Velavan S.

Abstract: Carbohydrates moieties of glycoproteins have also been implicated in the transport of metabolites across cell membranes and also observed a direct relationship between glycolproteins and tumorigenesis. In the present study to evaluate the glycoproteins as hexose, hexosamine and sialic acid have been measured in the plasma and liver tissues. This study shows that Aplotaxis auriculata root extract (AARE) administration decrease the glycoprotein synthesis in tumor cells. This may be due to the inhibitory action of AARE on the initiation of Diethylnitrosamine (DEN) activation/detoxification process. AARE offer promise as potential protective effect on carbohydrates moieties as glycoproteins against DEN treated rats.

Keywords: Glycolproteins, Diethylnitrosamine, Aplotaxis auriculata,