The Influence of Cytokine Profile and Choice of Surgical Intervention in Patients with Obesity

Todor Dimitrov DMD, Grigor Gorchev Prof. D.Sc., Slavcho Tomov Prof. D.Sc.

Abstract: Endometrial carcinoma is the most common type of gynecological carcinomas. Several biological mechanisms trace the relationship between obesity and endometrial neoplastic risk. In surgical practice, there has been increasing interest concerning a group of cytokines as an independent prognostic factor for aggression and the possible therapeutic impact on the neoplastic process. The high-tech surgical capabilities of minimally invasive surgery and the immunological changes at cytokine level in level I endometrial carcinoma enabled the increasingly successful treatment of this neoplastic disease and its prevention. The cytokine profile can be used as an assessment factor of primary neoplastic immune damage, as well as for the selection of a surgical intervention.

Keywords: stage I endometrial carcinoma, cytokine profile, obesity, robotic surgery