Antibacterial Spectrum and Activity Guided Evaluation of Bark of Sonneratia Alba

Mitter C. S.

Abstract: The present study has been undertaken to investigate bioactive compounds from bark of Sonneratia alba. Extracts were made in acetone, ethyl acetate and water by using powder of bark of S. alba. Bioassay of primary screening and MIC were done by disc diffusion method using various gram negative and gram positive bacteria. Maximum inhibition was shown against Klebsiella pneumoneae by acetone and aqueous extract and against Corynebacterium diphtheriae by aqueous extracts. MIC of all potent extracts displayed promising inhibitory activity against susceptible microorganisms. Activity Guided Fractionation of highly potent extracts indicated active principles mainly dissolved in polar solvents.

Keywords: Bioactive compounds, S alba, Bioassay, MIC and activity guided fractionation