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Research Paper | Pharmacology Science | India | Volume 4 Issue 4, April 2015

Evaluation of Antimitogenic and Cytotoxic Potential of Anacardiumoccidentale Leaf Extracts in Allumcepa Root Tip Cells and Against Sarcoma-180 Cells

Pralay Maity | Madhubanti Bepari | Sujata Maiti Choudhury

Abstract: Anacardium occidentale of family Anacardiaceae is a tropical tree and used traditionally for the treatment of different diseases. In the present study, we have evaluated the anti-mitotic and cytotoxic activities of ethanolic (EEAOL), methanolic (MEAOL) and water (WEAOL) extracts of Anacardium occidentaleleaf in Allium cepa root tip cells and against Sarcoma-180 cell lines. Ethanol, methanol, and water extracts were prepared from pulverized powder obtained from shed-dried leaves of Anacardium occidentale. The antimitotic activity was measured using Allium cepa root meristematic cells. The studies were extended to Sarcoma-180 cell lines to obtain the cytotoxic potential of the plant. Anacardium occidentaleextracts were found to be antimitotic for Allium cepa root tip cells at the concentration of 100mg/ml and also exhibited in vitro cytotoxicity against Sarcoma-180 cell lines at100 g/ml concentration. These findings reveal that Anacardium occidentaleleaf possesses pronounced antimitotic and cytotoxic potential in Alliumcepa root and against Sarcoma-180 cell lines.

Keywords: Anacardium occidentale, Allium cepa, S-180 cell, Antimitotic, Cytotoxic

Edition: Volume 4 Issue 4, April 2015,

Pages: 290 - 293