Conventional & Microwave-Assisted Synthesis and Antimicrobial Evaluation of Pyrimidine Azo Compounds

Shahana Ehsan, Aneeqa Ishfaq, Bushra Khan, Tahira Saghir, Sehrish Ghafoor

Abstract: Pyrimidine derivatives are an important class of heterocycles and significant bioactive moieties with wide range of biological activities such as, antibacterial, anti- inflammatory, antihypertensive, antitumor and calcium channel blocking activity. The coupling of certain pyrimidine derivatives (e. g. barbituric acid) with azo compounds and their further metallation with transition metals give rise to bioactive moieties along with diverse industrial applications. This study will report the synthesis and characterization of pyrimidine complexes and its derivatives by conventional and microwave-assisted synthetic routes. Furthermore, both methods will be compared to elaborate the advantages associated with microwave-assisted synthesis

Keywords: azo compounds, barbituric acid, pyrimidine complexes, microwave assisted method