Do Patients With Thalassaemia Major Manifest Endocrine Complications? Can We Solve Them?

Manika Kreka, Eleni Nastas, Xhensila Prendushi, Irena Qendro, Bledi Kreka, Vjollca Shpata

Abstract: It is estimated that endocrine abnormalities are present in thalasaemic patients. Despite the early diagnosis and the optimal iron chelation therapy, there are still important in many clinical situations like: delayed sexual maturation and impaired fertility. The aim of the study was to assess the correlation of ferritin level and growth and sexual hormones of organism in inidividuals with thalassaemia. A statistically negative correlation was found between ferritin level at the end of third year of treatment with Deferasirox and testosterone, (r=-0.6 p

Keywords: thalassaemia, iron, deferasirox, delayed puberty, hypogonadism