Synthesis, Anticancer and Anti-Microbial Characterization of Some Novel Quinazoline Derivatives

Manish Chaudhari, J.J.Vora

Abstract: With an objective to synthesize compounds with high anti-cancer and other anti-microbial properties, a systematically planned organic synthesis was carried out. Quinazoline has been a very significant heterocycle and also folic acid is having highly significant physiological activity. It was thought that combination of these two fragments must give resistant molecules with highly enhanced biological properties. With this ambiguous objective, the organic synthesis was carried out. The synthesized compounds were characterized by sensitive instrumental methods like Mass Spectra, 13C NMR, Infra-Red Spectra, UV Spectra etc. Their structures were thus confirmed by different physicochemical methods.

Keywords: Anticancer Activity, Antimicrobial Activity, Quinazoline derivatives and Amino Acid Derivatives