Histomorphological Study of Transurethral Resection of Prostate (TURP) Specimens with Incidental Detection of Prostatic Adenocarcinoma: A Retrospective Study from a Tertiary Care Centre in Northeast India
Abstract: Background: Benign prostatic hyperplasia (BPH) is the most common pathological condition affecting the ageing prostate and is a major cause of lower urinary tract symptoms. Transurethral resection of the prostate (TURP) is the standard surgical procedure for symptomatic BPH. Histopathological examination of TURP specimens not only confirms benign pathology but may also reveal unsuspected prostatic adenocarcinoma, thereby influencing further patient management. Objective: To evaluate the histomorphological spectrum of TURP specimens and determine the incidence and histopathological characteristics of incidentally detected prostatic adenocarcinoma. Materials and Methods: A retrospective observational study was conducted in the Department of Pathology, Assam Medical College, Dibrugarh, over a 14-month period from June 2024 to July 2025. Fifty-five TURP specimens received from patients clinically diagnosed with benign prostatic hyperplasia were included. Routine haematoxylin and eosin-stained sections were examined for histomorphological diagnosis. Incidentally detected carcinomas were graded using the Gleason grading system and classified into Grade Groups. Results: Among 55 TURP specimens, benign prostatic hyperplasia was identified in 48 (87.3%) cases, while incidental prostatic adenocarcinoma was detected in 7 (12.7%) cases. The majority of patients belonged to the 60-69-year age group. Of the seven malignant cases, five occurred in patients aged 60-69 years and two in those aged 70-79 years. Grade Group 1 (Gleason score 3+3=6) was the commonest histological grade, accounting for three cases. Conclusion: Histopathological examination of all TURP specimens remains essential, as clinically unsuspected prostatic adenocarcinoma may be detected incidentally. Accurate microscopic evaluation and Gleason grading facilitate appropriate postoperative management and prognostication, emphasizing the indispensable role of routine pathological assessment.
Keywords: Benign prostatic hyperplasia, Transurethral resection of prostate, Incidental prostatic adenocarcinoma, Histopathology
How to Cite?: Dr. Faud Amin Islam, Dr. Mandita Borgohain, "Histomorphological Study of Transurethral Resection of Prostate (TURP) Specimens with Incidental Detection of Prostatic Adenocarcinoma: A Retrospective Study from a Tertiary Care Centre in Northeast India", Volume 15 Issue 9, September 2026, International Journal of Science and Research (IJSR), Pages: 1938-1942, https://www.ijsr.net/getabstract.php?paperid=SR26927081937, DOI: https://dx.doi.org/10.21275/SR26927081937