A Young Male with ISAACS' Syndrome - A Case Report
Abstract: Peripheral nerve hyperexcitability syndromes are a group of disorders characterized by muscle stiffness, cramps, and muscle twitches with involuntary abnormal electrical activity on needle EMG. These rare diagnoses include cramp-fasciculation syndrome, Isaacs syndrome, and Morvan syndrome. We report a case of a 31-year-old young male, presented with history of multiple episodes of cramps of both lower limbs, burning sensation of both thighs, twitching over both calves, increased sweating. Auto immune encephalitis panel showed CASPR 2 and LGI 1 (VGKC associated antibodies) and improved with pulse steroid therapy, gabapentin, carbamazepine treatment.
Keywords: Peripheral nerve hyperexcitability, muscle cramps, muscle twitching, CASPR2 antibodies, LGI1 antibodies
How to Cite?: Dr. D. Nityata, Dr. Balaji G., Dr. Hariharan S, "A Young Male with ISAACS' Syndrome - A Case Report", Volume 15 Issue 9, September 2026, International Journal of Science and Research (IJSR), Pages: 1464-1466, https://www.ijsr.net/getabstract.php?paperid=SR26918132704, DOI: https://dx.doi.org/10.21275/SR26918132704