Association Between Angiotensin-Converting Enzyme (ACE) Gene Insertion / Deletion Polymorphism and Recurrent Pregnancy Loss: A Systematic Review of Published Studies
Abstract: Recurrent pregnancy loss (RPL) is a multifactorial reproductive disorder in which genetic, vascular, endocrine, immune, and environmental factors may interact. Angiotensin-converting enzyme (ACE) is an important component of the renin-angiotensin system and contributes to vascular tone, endothelial function, fibrinolysis, and uteroplacental circulation. The ACE insertion/deletion (I/D) polymorphism has consequently been investigated as a possible genetic susceptibility factor for RPL, although individual studies have reported inconsistent findings. The present systematic review and meta-analysis synthesised 26 eligible case-control studies comprising 3,140 women with RPL and 3,370 healthy controls. Methodological quality was assessed using the Newcastle-Ottawa Scale. Associations were examined using odds ratios (ORs) with 95% confidence intervals (CIs) under five genetic models. Significant associations were observed under the allelic model (I vs. D: OR = 0.538, 95% CI = 0.451-0.643, p
Keywords: ACE I/D polymorphism, recurrent pregnancy loss, genetic association, meta-analysis, renin-angiotensin system, genetic susceptibility
How to Cite?: Sadia Sadaf, Dr. Saptarshi Sen Gupta, "Association Between Angiotensin-Converting Enzyme (ACE) Gene Insertion / Deletion Polymorphism and Recurrent Pregnancy Loss: A Systematic Review of Published Studies", Volume 15 Issue 8, August 2026, International Journal of Science and Research (IJSR), Pages: 1817-1821, https://www.ijsr.net/getabstract.php?paperid=SR26826154659, DOI: https://dx.doi.org/10.21275/SR26826154659