Chronic Hypothyroidism Induced Pituitary Hyperplasia: A Reversible Cause of Pituitary Enlargement in Adolescence
Abstract: Background: Primary hypothyroidism is an important and often overlooked endocrine cause of short stature and delayed puberty in adolescents. Chronic untreated hypothyroidism may lead to pituitary thyrotroph hyperplasia, which can radiologically mimic pituitary macroadenoma. Differentiating between these entities is critical since hypothyroidism-induced pituitary hyperplasia resolves with thyroid hormone replacement, whereas macroadenomas may require surgical intervention. Clinical Description: We report a 13-year-old female who presented with short stature, delayed puberty, generalized edema, and recurrent morning vomiting. She was prepubertal (SMR stage I) with height and weight corresponding to 6- and 8-year equivalents, respectively. Management: Investigations revealed markedly elevated TSH (933.62 mIU/L) and low FT4 (
Keywords: Primary hypothyroidism, pituitary hyperplasia, short stature, delayed puberty, adolescent endocrinology
How to Cite?: Dr. Smrati Jain, Dr. Anjali, "Chronic Hypothyroidism Induced Pituitary Hyperplasia: A Reversible Cause of Pituitary Enlargement in Adolescence", Volume 15 Issue 8, August 2026, International Journal of Science and Research (IJSR), Pages: 1428-1429, https://www.ijsr.net/getabstract.php?paperid=SR26820234633, DOI: https://dx.doi.org/10.21275/SR26820234633