Ochronotic Arthropathy Presenting as Bilateral Hip Osteoarthritis with Right Femoral Head Necrosis: A Case Report

Pranav Kumar, Anchana Gulati, Digvijay Singh Dattal, Deepika Sharma

Abstract: Alkaptonuria is an autosomal recessive metabolic disorder caused by homogentisate 1,2-dioxygenase deficiency. It leads to the accumulation of homogentisic acid in connective tissues, resulting in a condition known as ochronosis. We present a case of a 50-year-old female with a known history of ochronosis who presented with bilateral hip pain and walking difficulty. She reported a history of passing black-colored urine since childhood. Imaging revealed bilateral hip osteoarthritis with right femoral head necrosis, bilateral acetabular ischemia, and protrusion acetabuli. The patient underwent a right-sided total hip replacement. Histopathology confirmed the presence of pigmented ochronotic bodies and a foreign body giant cell reaction. Joint replacement remains a highly effective treatment for end-stage ochronotic arthropathy.

Keywords: Alkaptonuria, Ochronosis, Ochronotic Arthropathy, Total Hip Replacement

How to Cite?: Pranav Kumar, Anchana Gulati, Digvijay Singh Dattal, Deepika Sharma, "Ochronotic Arthropathy Presenting as Bilateral Hip Osteoarthritis with Right Femoral Head Necrosis: A Case Report", Volume 15 Issue 7, July 2026, International Journal of Science and Research (IJSR), Pages: 2096-2098, https://www.ijsr.net/getabstract.php?paperid=SR26723204439, DOI: https://dx.doi.org/10.21275/SR26723204439

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