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Experimental Research Paper | Chemistry | Volume 15 Issue 7, July 2026 | Pages: 1824 - 1829 | India
Kinetic and Mechanistic Investigation of the Oxidation of Some α-Amino Acids by bis(2,6-dimethylpyridinium) Dichromate
Abstract: The kinetics and mechanism of oxidation of selected α-amino acids by bis(2,6-dimethylpyridinium) dichromate (BDMPDC) were investigated in glacial acetic acid in the presence of p-toluenesulphonic acid (TsOH). The reaction exhibits first-order dependence on BDMPDC and fractional-order dependence on both hydrogen ion and amino acid concentrations, with the latter approaching second order. Michaelis?Menten-type kinetics were observed with respect to the substrate. No significant kinetic isotope effect was detected during the oxidation of perdeuterioglycine. A small negative reaction constant obtained from correlation with Taft σ* substituent constants suggests the involvement of an electron-deficient transition state. The results indicate the formation of an intermediate complex between protonated amino acid and protonated BDMPDC, which decomposes in the rate-determining step to yield an iminium cation, followed by rapid formation of the final oxidation products.
Keywords: kinetics; α-amino acid; oxidation; Taft σ* constants
How to Cite?: Dinesh Panday, "Kinetic and Mechanistic Investigation of the Oxidation of Some α-Amino Acids by bis(2,6-dimethylpyridinium) Dichromate", Volume 15 Issue 7, July 2026, International Journal of Science and Research (IJSR), Pages: 1824-1829, https://www.ijsr.net/getabstract.php?paperid=SR26721194357, DOI: https://dx.doi.org/10.21275/SR26721194357