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Research Paper | Obstetrics and Gynecology | Volume 15 Issue 7, July 2026 | Pages: 1023 - 1027 | India
Clinical Utility of Serum Homocysteine for Predicting Insulin Resistance in Women with Polycystic Ovary Syndrome
Abstract: Objectives: Polycystic ovary syndrome (PCOS) is a common disease among young women that causes hyperinsulinemia. Patients of PCOS are at increased risk of dyslipidemia and insulin resistance and much of their complications. Also, Hyperhomocysteinemia is shown to be correlated positively with the hyperinsulinemia. This study aimed to evaluate INSULIN RESISTANCE as a function of HOMAIR and its correlation with other serum metabolic and biochemical parameters amongst PCOS women. Methods: Fifty women with PCOS and 40 healthy subjects were studied. Hormonal assays, lipid profile, Hcy and fasting insulin levels, insulin resistance (IR) indices (HOMA) determinations and ultrasound evaluation were performed. Results: Mean of BMI was significantly higher in PCOS subjects as compared with the controls (26.82 ±3.62 vs 24.65 ± 2.62 kg/m2; p = 0.002). The mean fasting insulin levels were also significantly higher (20.77 ± 9.69 vs 7.54 ± 3.55 lU/dl; p = 0.000) where we found no difference in fasting glucose concentrations between groups. IR indices in PCOS women were significantly higher than control group (p < 0.000). We observed significantly higher mean serum Hcy levels in PCOS patients (11.87 ± 5.55 vs 7.81 ± 2.29 lmol/l; p = 0.000). When patients were stratified by BMI, the Hcy concentration was not significantly difference in both obese and normal-weight PCOS women. Fasting insulin concentrations and IR indices were significantly higher in obese PCOS patients as opposed to normal-weight PCOS women. IR indices showed increasing trends with Hcy levels. Conclusions: Our study shows the tendency toward hyperhomocysteinaemia, hyperinsulinemia and higher BMI in PCOS patients. These factors are critical predictors of PCOS; however, BMI and IR are an independent risk factor to increase plasma Hcy levels in PCOS women.
Keywords: Polycystic ovary syndrome, Insulin resistance, HOMA-IR, Hyperhomocysteinemia, Lipid profile
How to Cite?: Shubhi Agarwal, Saket Ramraika, "Clinical Utility of Serum Homocysteine for Predicting Insulin Resistance in Women with Polycystic Ovary Syndrome", Volume 15 Issue 7, July 2026, International Journal of Science and Research (IJSR), Pages: 1023-1027, https://www.ijsr.net/getabstract.php?paperid=SR26708011003, DOI: https://dx.doi.org/10.21275/SR26708011003