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Original Research | General Surgery | Volume 15 Issue 7, July 2026 | Pages: 1878 - 1882 | India
Association of Helicobacter Pylori Infection and Surgical Outcomes in Gastroduodenal Perforation: A Prospective Comparative Study of Graham's Patch and Modified Graham's Patch Repair
Abstract: Background: Gastroduodenal perforation due to acid peptic disease remains a major emergency surgical condition, particularly in resource-limited settings. Helicobacter pylori infection is an important etiological factor in peptic ulcer disease, while the choice of operative repair may influence postoperative recovery. This study evaluated the association of H. pylori infection with gastroduodenal perforation and compared outcomes between Graham's Patch Repair and Modified Graham's Patch Repair. Aim: To determine the prevalence of H. pylori infection among patients with gastroduodenal perforation and compare the postoperative outcomes of Graham's Patch Repair and Modified Graham's Patch Repair. Materials and Methods: This prospective comparative study was conducted in the Department of Surgery, B.R.D. Medical College, Gorakhpur, from 2024 to 2026. A total of 114 patients with gastroduodenal perforation and peritonitis undergoing operative intervention were included. Patients with suspected malignant perforation, traumatic perforation, penetrating abdominal injury, or refusal of consent were excluded. Patients underwent either Graham's Patch Repair or Modified Graham's Patch Repair. H. pylori status was assessed using available intraoperative diagnostic methods. Postoperative complications, duration of hospital stay, time to resume oral feeding, recurrence and mortality were compared between groups. Data were analysed using appropriate statistical tests, with p<0.05 considered significant. Results: The study included 114 patients, most commonly aged 31-40 years (29.82%), with male predominance 78.07%. Acute abdominal pain was present in all patients, followed by vomiting 70.18% and abdominal distension 56.14%. Alcohol consumption 34.21% and smoking 30.70% were common risk factors. H. pylori positivity was observed in 36.84% of cases. Both surgical groups were equally distributed, with 50% undergoing Graham's Patch Repair and 50% undergoing Modified Graham's Patch Repair. There was no significant association between H. pylori status and surgical technique (p=0.846). Modified Graham's Patch Repair was associated with significantly shorter hospital stay (8.12 vs 10.56 days, p<0.001) and earlier oral feeding (2.18 vs 2.86 days, p<0.001). Recurrence was lower in the modified group but not statistically significant (5.26% vs 15.79%, p=0.067). Mortality was 0% in both groups. Conclusion: H. pylori infection was present in nearly one-third of patients with gastroduodenal perforation. Modified Graham's Patch Repair provided faster postoperative recovery than standard Graham's Patch Repair, with shorter hospital stay and earlier oral feeding, without increasing complications or mortality. Routine H. pylori testing, eradication therapy, timely surgery and structured postoperative care are important for reducing recurrence and improving outcomes.
Keywords: Helicobacter pylori, Gastroduodenal perforation, Graham's Patch Repair, Modified Graham's Patch Repair, Peptic ulcer disease, Surgical outcome
How to Cite?: Dr. Prakarsh Gupta, Dr. Sandesh Kumar Srivastava, Dr. Durgesh Kumar Tripathi, Dr. Kushagra Kumar, "Association of Helicobacter Pylori Infection and Surgical Outcomes in Gastroduodenal Perforation: A Prospective Comparative Study of Graham's Patch and Modified Graham's Patch Repair", Volume 15 Issue 7, July 2026, International Journal of Science and Research (IJSR), Pages: 1878-1882, https://www.ijsr.net/getabstract.php?paperid=SR26707162323, DOI: https://dx.doi.org/10.21275/SR26707162323