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Original Research | Pathology | Volume 15 Issue 6, June 2026 | Pages: 1551 - 1553 | India
Histomorphological Subtyping of Renal Cell Carcinoma: Diagnostic Utility of CK7, CAIX, and AMACR
Abstract: Background: Histological subtyping of renal cell carcinoma (RCC) is essential because different subtypes have distinct prognostic and therapeutic implications. Morphological overlap often makes diagnosis difficult, necessitating immunohistochemistry (IHC). Objectives: To classify RCC based on histomorphology and evaluate the role of CK7, CAIX, and AMACR in subtype differentiation. Methods: A prospective cross-sectional study was conducted over two years on 40 nephrectomy specimens diagnosed as RCC. Tumors were classified on hematoxylin and eosin sections and graded according to the ISUP grading system. IHC was performed using CK7, CAIX, and AMACR. Statistical analysis was done using SPSS version 26. Results: The mean age was 56.9 ? 13.0 years. Clear cell RCC was the commonest subtype (47.5%), followed by papillary RCC (35%), chromophobe RCC (10%), and clear cell papillary RCC (7.5%). CAIX showed positivity in all clear cell RCCs, while AMACR was positive in all papillary RCCs. CK7 was positive in all chromophobe and clear cell papillary RCCs and in 85.7% of papillary RCCs. The association between histological subtype and marker expression was statistically significant (p<0.001). Conclusion: The combined use of CK7, CAIX, and AMACR accurately differentiates the major RCC subtypes and is a valuable adjunct to routine histopathological evaluation.
Keywords: Renal cell carcinoma, Immunohistochemistry, CK7, CAIX, AMACR
How to Cite?: Dr. Titir Saha, Dr Sumit Nandy, Dr. Ananya Roy, Dr Aditi Bhattacharya, "Histomorphological Subtyping of Renal Cell Carcinoma: Diagnostic Utility of CK7, CAIX, and AMACR", Volume 15 Issue 6, June 2026, International Journal of Science and Research (IJSR), Pages: 1551-1553, https://www.ijsr.net/getabstract.php?paperid=SR26628190744, DOI: https://dx.doi.org/10.21275/SR26628190744