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Original Research | Pathology | Volume 15 Issue 6, June 2026 | Pages: 935 - 939 | India
An Observational Study Evaluating the Role of Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Assessing Disease Activity in Ulcerative Colitis at a Tertiary Care Centre
Abstract: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by relapsing and remitting mucosal inflammation. Endoscopy remains the gold standard for assessing disease activity but is invasive and less suitable for frequent monitoring. This observational study evaluated the role of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) as non-invasive biomarkers of disease activity in UC. Forty-five clinicopathologically confirmed UC patients and 45 healthy controls were enrolled. Cases were classified into mild to moderate and severe disease according to the Truelove and Witts criteria. Hematological parameters, NLR, and PLR were calculated and compared between groups. Both NLR and PLR were significantly higher in UC patients than in controls and increased progressively with disease severity. ROC analysis demonstrated good diagnostic performance for both markers, with NLR showing superior sensitivity and diagnostic accuracy. The findings suggest that NLR and PLR are simple, inexpensive, and readily available biomarkers that may serve as useful adjuncts for assessing disease activity in ulcerative colitis, particularly where endoscopic evaluation is not readily available.
Keywords: Ulcerative Colitis, Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio, Disease Activity, Inflammatory Bowel Disease, Biomarkers
How to Cite?: Dr. Syeda Hafsa Razvi, Dr. R. Nagarjuna Chary, Dr. Naval Kishore Bajaj, "An Observational Study Evaluating the Role of Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Assessing Disease Activity in Ulcerative Colitis at a Tertiary Care Centre", Volume 15 Issue 6, June 2026, International Journal of Science and Research (IJSR), Pages: 935-939, https://www.ijsr.net/getabstract.php?paperid=SR26616234520, DOI: https://dx.doi.org/10.21275/SR26616234520