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Case Series | Medicine | Volume 15 Issue 6, June 2026 | Pages: 721 - 724 | India
Spectrum of Allergic Bronchopulmonary Aspergillosis: Insights from a Case Series Emphasizing Clinical and Immunoradiological Heterogeneity
Abstract: Allergic bronchopulmonary aspergillosis (ABPA) is an immunologically mediated lung disease caused by hypersensitivity to fungi, usually aspergillus fumigatus colonizing the airways of patients with underlying chronic lung diseases most commonly bronchial asthma and cystic fibrosis. Despite improved awareness and understanding of this disease, it still remains underdiagnosed and, in some cases, misdiagnosed as tuberculosis, as noted in our case series; to the detriment of patients who can progress irrevocably towards bronchiectasis, fibrosis, chronic airflow limitation with complications of pulmonary hypertension (PH) and respiratory failure (RF) if not treated early and adequately. This case series of 30 patients fulfilling revised ISHAM (International Society for Human and Animal Mycology) criteria for ABPA highlights the heterogenicity in clinical presentation, the need for definitive diagnosis using radiological criteria and biomarkers, and prompt treatment with anti-inflammatory and anti-fungal agents. Our case series emphasizes the need to vigorously investigate every patient with moderate to severe obstructive airway disease (OAD) for ABPA since early detection will control and reduce exacerbations of OAD, thus improving quality of life and prevent progression to bronchiectasis and complications like PH and RF. Research Question: What is the prevalence and clinical?radiological and immunological profile of ABPA among patients admitted with chronic airway diseases in a tertiary care center?
Keywords: Asthma, ABPA, Bronchiectasis, IgE, Absolute eosinophil count
How to Cite?: Dr. Lavina Mirchandani, Dr. Prarabdh A. Modi, Dr. Girija Nair, Dr. Shahid Patel, "Spectrum of Allergic Bronchopulmonary Aspergillosis: Insights from a Case Series Emphasizing Clinical and Immunoradiological Heterogeneity", Volume 15 Issue 6, June 2026, International Journal of Science and Research (IJSR), Pages: 721-724, https://www.ijsr.net/getabstract.php?paperid=SR26613234415, DOI: https://dx.dx.doi.org/10.21275/SR26613234415