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Original Research | Pharmaceutical Science | Volume 15 Issue 6, June 2026 | Pages: 284 - 293 | India
Efficacy of Daily Supplementation of Vitamin D3 Nano Oral Spray vis-a-vis Other Vitamin D3 Formulations in Vitamin D-deficient Indian Adults: RCT
Abstract: Background: This is a randomised controlled trials (RCTs), assessing the effectiveness of a nano vitamin D3 oral mucosal spray against nano and fat-soluble vitamin D3 tablets. Method: Of 324 enrolled participants, 298 completed the 3-month intervention. Subjects were assigned to four groups: Group A received 1000 IU DEKSEL? Nano Oral Spray, Group B received DENCIUM ND3? tablets (1000 IU nano vitamin D3 plus calcium), Group C received TAYO tablets (1000 IU conventional vitamin D3 plus calcium), and Group D received 2000 IU DEKSEL? Nano Oral Spray. High-performance liquid chromatography analysis showed that the actual vitamin D3 content in all formulations exceeded the labeled dose. Serum 25-hydroxyvitamin D [25(OH)D], parathyroid hormone, 1,25-dihydroxyvitamin D, calcium, phosphate, alkaline phosphatase, and urinary calcium/creatinine ratio were assessed before and after supplementation. Results: All groups demonstrated significant increases in serum 25(OH)D concentrations after 3 months (p<0.001), with the greatest increase observed in the higher-dose oral spray group. Although overall intergroup differences were not significant, the rise in serum 25(OH)D per 100 IU of vitamin D3 was significantly greater with the nano oral spray than with the conventional tablet formulation. Conclusion: The study concluded that nano vitamin D3 oral spray is more effective than tablet formulations in improving vitamin D status and may be particularly useful for individuals with malabsorption or difficulty swallowing tablets.
Keywords: Randomized study, Nano vitamin D3 tablet, Vitamin D3 nano oral spray, conventional vitamin D3, serum 25(OH)D, PTH and 1,25(OH)2D
How to Cite?: Dr. R. K. Marwaha, Dr. Meeta, Dr. Kalaivani Mani, Dr. Shariq Masoodi, Dr. Vivek Dixit, Dr. Archna Narang, Dr. Arjun Dang, Dr. Seema Rai, "Efficacy of Daily Supplementation of Vitamin D3 Nano Oral Spray vis-a-vis Other Vitamin D3 Formulations in Vitamin D-deficient Indian Adults: RCT", Volume 15 Issue 6, June 2026, International Journal of Science and Research (IJSR), Pages: 284-293, https://www.ijsr.net/getabstract.php?paperid=SR26603092133, DOI: https://dx.dx.doi.org/10.21275/SR26603092133