Downloads: 14
Original Research | Pharmaceutical Science | Volume 15 Issue 6, June 2026 | Pages: 284 - 293 | India
Efficacy of Daily Supplementation of Vitamin D3 Nano Oral Spray vis-a-vis Other Vitamin D3 Formulations in Vitamin D-deficient Indian Adults: RCT
Abstract: Background: This is a randomised controlled trials (RCTs), assessing the effectiveness of a nano vitamin D3 oral mucosal spray against nano and fat-soluble vitamin D3 tablets. Method: Of 324 enrolled participants, 298 completed the 3-month intervention. Subjects were assigned to four groups: Group A received 1000 IU DEKSEL? Nano Oral Spray, Group B received DENCIUM ND3? tablets (1000 IU nano vitamin D3 plus calcium), Group C received TAYO tablets (1000 IU conventional vitamin D3 plus calcium), and Group D received 2000 IU DEKSEL? Nano Oral Spray. High-performance liquid chromatography analysis showed that the actual vitamin D3 content in all formulations exceeded the labeled dose. Serum 25-hydroxyvitamin D [25(OH)D], parathyroid hormone, 1,25-dihydroxyvitamin D, calcium, phosphate, alkaline phosphatase, and urinary calcium/creatinine ratio were assessed before and after supplementation. Results: All groups demonstrated significant increases in serum 25(OH)D concentrations after 3 months (p
Keywords: Randomized study, Nano vitamin D3 tablet, Vitamin D3 nano oral spray, conventional vitamin D3, serum 25(OH)D, PTH and 1,25(OH)2D
How to Cite?: Dr. R. K. Marwaha, Dr. Meeta, Dr. Kalaivani Mani, Dr. Shariq Masoodi, Dr. Vivek Dixit, Dr. Archna Narang, Dr. Arjun Dang, Dr. Seema Rai, "Efficacy of Daily Supplementation of Vitamin D3 Nano Oral Spray vis-a-vis Other Vitamin D3 Formulations in Vitamin D-deficient Indian Adults: RCT", Volume 15 Issue 6, June 2026, International Journal of Science and Research (IJSR), Pages: 284-293, https://www.ijsr.net/getabstract.php?paperid=SR26603092133, DOI: https://dx.doi.org/10.21275/SR26603092133