In Vitro Anti-Obesity Effects of Medicinal Mushroom Extracts on Adipocyte Lipid Metabolism, Inflammation, and Oxidative Stress: A Nutraceutical Approach
Abstract: This study evaluated the in vitro anti-obesity potential of medicinal mushroom extracts from Chaga (Inonotus obliquus), Fuscoporia gilva, and Bracket fungi using adipocyte-related assays. Antioxidant activity was assessed using DPPH radical scavenging; anti-inflammatory potential by a protein denaturation assay; cytotoxicity by an MTT assay; and lipid accumulation by triglyceride quantification in differentiated adipocyte-like cells. Combination extracts demonstrated stronger antioxidant and anti-inflammatory activity than several individual extracts, suggesting possible synergistic effects. Treatment also reduced triglyceride accumulation in mature adipocyte-like cells while maintaining acceptable cell viability at tested concentrations. These findings indicate that medicinal mushroom extracts may possess anti-obesity-related bioactivity in vitro and warrant further in vivo validation for nutraceutical development.
Keywords: Obesity, Adipocytes, Inonotus obliquus, Fuscoporia gilva, Medicinal mushrooms, Nutraceuticals, Lipid accumulation, Oxidative stress, Anti-inflammatory activity
How to Cite?: Dr. Katepogu Harika, A. Ganga Devi, T. Lakshmi Prasanna, Murthineni Yuvaraj, Poreddy Kiran Tej Reddy, Bojanapu Revanth Kumar, Dr. Shilpa Nayuni, "In Vitro Anti-Obesity Effects of Medicinal Mushroom Extracts on Adipocyte Lipid Metabolism, Inflammation, and Oxidative Stress: A Nutraceutical Approach", Volume 15 Issue 5, May 2026, International Journal of Science and Research (IJSR), Pages: 1863-1870, https://www.ijsr.net/getabstract.php?paperid=SR26526003311, DOI: https://dx.doi.org/10.21275/SR26526003311