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Research Paper | Cardiology Science | Volume 15 Issue 5, May 2026 | Pages: 1573 - 1581 | India
Association of Clinical, Biochemical and Imaging Biomarkers with Coronary Artery Disease Severity: A Cross-Sectional Study
Abstract: Background: Coronary artery disease (CAD) remains the leading cause of mortality worldwide, with a disproportionately high burden in South Asian populations. Objective: To evaluate associations between clinical characteristics, inflammatory biomarkers, and imaging parameters with angiographically determined CAD severity using Gensini and SYNTAX scores in an Indian cohort. Methods: This cross-sectional study included 200 consecutive patients undergoing coronary angiography at a tertiary cardiac center in India (January 2023?December 2024). CAD severity was classified as mild, moderate, or severe. Statistical analyses included Kruskal-Wallis and chi-square tests, with multivariable logistic regression to identify independent predictors of severe CAD, adjusting for relevant clinical and biochemical covariates. Results: Hypertension, diabetes, interatrial septal thickness, hsCRP, and carotid intima-media thickness demonstrated significant graded associations with disease severity. In multivariable logistic regression, diabetes (OR 2.19), reduced eGFR (OR 0.60), and hsCRP (OR 1.46) independently predicted severe CAD. The predictive model demonstrated acceptable discrimination (AUC 0.758), with internal bootstrapping confirming minimal optimism. Conclusion: Inflammatory and structural imaging biomarkers, alongside comorbidities, demonstrated graded relationships with CAD severity, supporting multimodal risk stratification. The absence of coronary artery calcium scoring, lipoprotein(a) measurement, and epicardial adipose tissue quantification limits complete risk capture. These findings require external validation in larger cohorts before clinical implementation.
Keywords: Coronary artery disease, Gensini score, SYNTAX score, hsCRP, carotid intima-media thickness, interatrial septal thickness, inflammatory biomarkers, cardiovascular risk stratification, South Asian population
How to Cite?: Dr. Ashish M Kusare, Dr. Sunil Washimkar, Dr. Shereen Valsson, "Association of Clinical, Biochemical and Imaging Biomarkers with Coronary Artery Disease Severity: A Cross-Sectional Study", Volume 15 Issue 5, May 2026, International Journal of Science and Research (IJSR), Pages: 1573-1581, https://www.ijsr.net/getabstract.php?paperid=SR26524221702, DOI: https://dx.dx.doi.org/10.21275/SR26524221702