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Research Paper | Biomedical Sciences | Volume 15 Issue 4, April 2026 | Pages: 1489 - 1493 | India
EDXRF-Based Trace Elemental Analysis of Citrus aurantifolia Leaves with Emphasis on Anticancer Potential
Abstract: Cancer remains one of the most leading causes of mortality worldwide, and increasing attention has been directed toward plant-based therapeutics as complementary strategies in cancer management due to its rich bioactive compounds and lower side effects. Trace elements play vital roles in carcinogenesis, antioxidant defense, immune regulation, and cellular metabolism. The present study investigates the trace elemental composition of Citrus aurantifolia leaves using Energy Dispersive X-Ray Fluorescence (EDXRF) spectroscopy, with emphasis on their potential relevance to anticancer activity. EDXRF is a non-destructive analytical technique used for the qualitative and quantitative estimation of elemental composition present in a wide range of materials, including metals, biological samples, soils, and medicinal plants. EDXRF analysis revealed that, the presence of essential macro and microelements including K, Ca, Fe, Zn, Mn, Cu, Sr, and trace levels of Cr, Ni, and Pb. Potassium and calcium were found in higher concentrations, whereas biologically important micronutrients such as Fe, Zn, and Mn were present in moderate amounts. These elements are known to contribute to antioxidant enzyme systems, DNA repair mechanisms, and immune modulation associated with cancer prevention. The results support the therapeutic potential of Citrus aurantifolia leaves and highlight their significance as a natural source of bioactive trace elements for complementary anticancer applications. Future studies should focus on validating the anti-cancer activity via bio-assays, integrate advanced analytical techniques, assess bioavailability and toxicity, and develop standardized Citrus aurantifolia formulations for therapeutic use.
Keywords: Citrus aurantifolia, EDXRF analytical technique, Trace elements, Elemental composition, Medicinal plants and Cancer disease
How to Cite?: D. Sammaiah, S. Jyothsna, "EDXRF-Based Trace Elemental Analysis of Citrus aurantifolia Leaves with Emphasis on Anticancer Potential", Volume 15 Issue 4, April 2026, International Journal of Science and Research (IJSR), Pages: 1489-1493, https://www.ijsr.net/getabstract.php?paperid=SR26421170449, DOI: https://dx.dx.doi.org/10.21275/SR26421170449