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Research Paper | Information Technology | Volume 15 Issue 4, April 2026 | Pages: 1027 - 1033 | India
CRISPR-Cas9 and Genomic Technologies in Precision Medicine: Transforming Disease Diagnosis, Therapy, and Personalized Treatment
Abstract: This review examines the integration of CRISPR-Cas9 with genomic technologies in advancing precision medicine. It outlines the scientific basis of CRISPR systems and their convergence with next-generation sequencing, bioinformatics, and artificial intelligence. The study synthesizes current literature across oncology, inherited disorders, infectious diseases, and neurological conditions, and compares emerging gene-editing platforms including base and prime editing. Evidence from recent clinical studies, including CRISPR-based therapies, demonstrates significant progress toward targeted and curative interventions. Key challenges such as off-target effects, ethical concerns, and data inequity are also analyzed. The review concludes that genomic technologies are shifting medicine toward proactive, genotype-driven care, though further work is needed to ensure safety, accessibility, and regulatory clarity.
Keywords: CRISPR-Cas9, Genomics, Precision Medicine, Gene Editing, Next-Generation Sequencing, Personalized Therapy, Base Editing, Oncogenomics, Bioinformatics, Epigenomics, CRISPR Therapeutics, Genome Editing Safety, Clinical Genomics Implementation
How to Cite?: Arshpreet Kaur Kohli, Raghu Raja Mehra, "CRISPR-Cas9 and Genomic Technologies in Precision Medicine: Transforming Disease Diagnosis, Therapy, and Personalized Treatment", Volume 15 Issue 4, April 2026, International Journal of Science and Research (IJSR), Pages: 1027-1033, https://www.ijsr.net/getabstract.php?paperid=SR26416190608, DOI: https://dx.dx.doi.org/10.21275/SR26416190608