Face Predicts the Brain: Prenatal Ultrasound Diagnosis of Alobar Holoprosencephaly with Multisystem Anomalies - A Rare Case Report
Abstract: Holoprosencephaly is a rare congenital malformation resulting from incomplete cleavage of the forebrain and is frequently associated with severe craniofacial and systemic anomalies. We present a case of a 16-week intrauterine fetus diagnosed on antenatal ultrasonography with alobar holoprosencephaly and multiple associated anomalies. Ultrasound revealed a monoventricle with fused thalami, absent midline structures, and severe facial dysmorphism including absent orbits and a midline proboscis. Associated findings included a cystic lesion suggestive of a foregut duplication cyst, complex congenital heart disease, and bilateral echogenic kidneys. These findings indicate a poor prognosis and are highly suggestive of a syndromic association, most commonly trisomy 13.
Keywords: holoprosencephaly, fetal anomalies, prenatal ultrasound, trisomy thirteen, congenital malformations
How to Cite?: Dr. Kishan Ashok Bhagwat, Dr. Jeevika M U, Dr. Shashank D Raghavan, "Face Predicts the Brain: Prenatal Ultrasound Diagnosis of Alobar Holoprosencephaly with Multisystem Anomalies - A Rare Case Report", Volume 15 Issue 4, April 2026, International Journal of Science and Research (IJSR), Pages: 590-592, https://www.ijsr.net/getabstract.php?paperid=SR26408192230, DOI: https://dx.doi.org/10.21275/SR26408192230