Herpes Simplex Virus 2 Encephalitis Followed by Anti NMDAR Encephalitis in an Immunocompetent Adult: Five Year Follow Up Case Report
Abstract: Background: Autoimmune encephalitis following HSV2 encephalitis is exceptionally rare in immunocompetent adults. Purpose: To describe a longitudinal clinical course of Herpes Simplex Virus 2 (HSV2) encephalitis followed by anti NMDAR encephalitis. Methods: Detailed clinical, neuroimaging, electrophysiological, and cerebrospinal fluid analyses with five years follow up were conducted. Results: The patient developed post infectious autoimmune encephalitis characterized by focal seizures, cognitive behavioral changes, and positive NMDAR antibodies, responding to corticosteroid and antiepileptic therapy. Conclusion: This case highlights the need for long term autoimmune surveillance after HSV2 encephalitis and suggests favorable prognosis with early immunotherapy.
Keywords: HSV2 encephalitis, autoimmune encephalitis, anti NMDAR antibodies, immunocompetent adult
How to Cite?: Mirena Valkova, Elena Tzolova, Dayana Vidova, "Herpes Simplex Virus 2 Encephalitis Followed by Anti NMDAR Encephalitis in an Immunocompetent Adult: Five Year Follow Up Case Report", Volume 15 Issue 3, March 2026, International Journal of Science and Research (IJSR), Pages: 1609-1611, https://www.ijsr.net/getabstract.php?paperid=SR26325125225, DOI: https://dx.doi.org/10.21275/SR26325125225