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Review Papers | Chemistry | Volume 15 Issue 3, March 2026 | Pages: 1293 - 1302 | India
Green Synthesis of Biologically Significant Pyrano and Pyrido Pyrimidine Derivatives: A Review
Abstract: Pyrimidine derivatives are an important class of heterocyclic compounds known for their diverse biological activities, such as anticancer, antiviral, antibacterial, and antifungal properties. The synthesis of these compounds traditionally involves the use of toxic chemicals and harsh reaction conditions, which are detrimental to both the environment and human health. In recent years, green chemistry approaches have emerged as viable alternatives to conventional methods. This review summarizes recent advances in environmentally benign synthetic strategies for pyrano and pyrido pyrimidine derivatives with established pharmacological relevance. The analysis focuses on solvent free reactions, green catalysts, microwave and ultrasound assisted methodologies, and multicomponent protocols reported in contemporary literature. Comparative assessment indicates that non-conventional activation techniques significantly reduce reaction time and environmental burden while improving yields and selectivity. The review highlights mechanistic trends and identifies research gaps in scalable sustainable synthesis for drug discovery. These findings support the continued integration of green chemistry principles in heterocyclic medicinal chemistry.
Keywords: Microwave assisted synthesis, ultrasound assisted synthesis, multicomponent reactions, heterocyclic medicinal chemistry and green catalysis
How to Cite?: Rohit Chandrakant Muthe, Dr. Namdeo Mangu Chavhan, "Green Synthesis of Biologically Significant Pyrano and Pyrido Pyrimidine Derivatives: A Review", Volume 15 Issue 3, March 2026, International Journal of Science and Research (IJSR), Pages: 1293-1302, https://www.ijsr.net/getabstract.php?paperid=SR26320103315, DOI: https://dx.dx.doi.org/10.21275/SR26320103315