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Review Papers | Pharmaceutical Science | Volume 15 Issue 3, March 2026 | Pages: 901 - 907 | India
Solid Dispersion Technology for Enhancement of Solubility and Bioavailability: A Comprehensive Review
Abstract: Limited aqueous solubility remains a critical obstacle in the successful oral delivery of many therapeutic agents, particularly drugs categorized under Biopharmaceutics Classification System (BCS) class II and IV. Inadequate solubility leads to slow dissolution, insufficient gastrointestinal absorption, and poor oral bioavailability, ultimately compromising therapeutic effectiveness and contributing to variability in patient response. Solid dispersion (SD) technology has emerged as an effective and adaptable formulation approach to overcome these challenges without altering the chemical integrity of drug molecules. In SD systems, one or more active pharmaceutical ingredients are uniformly dispersed within hydrophilic carriers or polymeric matrices at the molecular or particulate level. This dispersion enhances drug wettability, reduces effective particle size, suppresses crystallinity, stabilizes amorphous forms, and significantly improves dissolution behavior. The present review provides an in-depth and systematic discussion of solid dispersion technology, encompassing its historical development, classification systems, formulation principles, preparation techniques, and characterization methods. In addition, the review highlights the underlying mechanisms responsible for solubility and bioavailability enhancement, pharmaceutical and industrial applications, stability considerations, regulatory requirements, scale-up challenges, recent advancements, and future perspectives.
Keywords: Solid dispersion, solubility enhancement, bioavailability, amorphous solid dispersions, hydrophilic polymers, oral drug delivery
How to Cite?: Sarangdevot PS, Solanki NS, "Solid Dispersion Technology for Enhancement of Solubility and Bioavailability: A Comprehensive Review", Volume 15 Issue 3, March 2026, International Journal of Science and Research (IJSR), Pages: 901-907, https://www.ijsr.net/getabstract.php?paperid=SR26310151716, DOI: https://dx.dx.doi.org/10.21275/SR26310151716