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Original Article | Pathology | Volume 15 Issue 3, March 2026 | Pages: 656 - 658 | India
Evaluation of Tumor Associated Macrophages and Vascular Endothelial Growth Factor Receptor expression in Colorectal Carcinoma: An Immunohistochemical Correlation Study
Abstract: Colorectal cancer (CRC) is one of the most common malignancies worldwide and its progression is influenced by the tumor microenvironment. Tumor-associated macrophages (TAMs), particularly the M2 phenotype, play a critical role in tumor progression, immune suppression and angiogenesis. Vascular endothelial growth factor receptor (VEGFR) signaling is a major driver of tumor angiogenesis. This study aimed to evaluate the correlation between tumor-associated macrophages and VEGFR expression in colorectal carcinoma using immunohistochemistry. A cross-sectional study was conducted on 52 cases of colorectal carcinoma received in the Department of Pathology, Osmania General Hospital, Hyderabad. Immunohistochemical staining was performed for CD163 to identify tumor-associated macrophages and VEGF to evaluate angiogenic activity. Expression levels were scored semi?quantitatively and correlated with clinicopathological parameters. Statistical analysis was performed using Spearman correlation and Chi-square tests. A strong positive correlation was observed between CD163 and VEGFR expression (Spearman ? = 0.659, p < 0.001). Increased expression of both markers was also associated with advanced tumor stage and aggressive pathological features. The study demonstrates that tumor-associated macrophages are significantly associated with increased VEGFR expression, suggesting their role in promoting tumor angiogenesis in colorectal carcinoma.
Keywords: Colorectal cancer, Tumor associated macrophages, CD163, VEGF, Angiogenesis, Immunohistochemistry
How to Cite?: Farah Naaz, Kotta Devender Reddy, Naval Kishore, "Evaluation of Tumor Associated Macrophages and Vascular Endothelial Growth Factor Receptor expression in Colorectal Carcinoma: An Immunohistochemical Correlation Study", Volume 15 Issue 3, March 2026, International Journal of Science and Research (IJSR), Pages: 656-658, https://www.ijsr.net/getabstract.php?paperid=SR26309150741, DOI: https://dx.dx.doi.org/10.21275/SR26309150741