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Research Paper | Pharmacology Science | Volume 15 Issue 4, April 2026 | Pages: 1427 - 1440 | India
Preliminary Phytochemical Screening and in Vitro Anti-Urolithiatic Activity of Methanol Extract on Leaves of Artocarpus Heterophyllus Lam
Abstract: Urolithiasis is still one of the commonest urological disorders, and herbal extracts offer potential preventive benefits through their diuretic, crystallization-inhibiting, lithotropic analgesic, and anti-inflammatory activities. This study aims to assess the methanolic extract of Artocarpus heterophyllus Lam. leaves as a natural remedy against the formation of kidney stones. The presence of preliminary alkaloids, flavonoids, triterpenoids, saponins, tannins, and phenolic compounds- bioactive constituents renowned for their antioxidant, anti-inflammatory, diuretic, and antimicrobial properties- is essential in the fight against urolithiasis. The extract displayed strong anti-urolithiatic effects in various in vitro tests. Using the titrimetric method, it accomplished around 60% dissolution of calcium oxalate crystals, nearly reaching the 80% efficacy of the standard drug cystone. Dose-dependent inhibition was observed in nucleation, with lower crystal size and count seen at higher concentrations through microscopic examination. These results support the traditional use of A. heterophyllus leaves for urinary disorders and underscore their potential as a safer substitute for synthetic treatments. Future in vivo and clinical studies are recommended to elucidate mechanisms, optimize formulations, isolate active compounds and establish safety profiles, paving the way for plant-based therapeutics in renal healthcare.
Keywords: Artocarpus heterophyllus, urolithiasis, anti-urolithiatic activity, calcium oxalate, titrimetric assay, nucleation inhibition, aggregation assay, phytochemical screening
How to Cite?: Nishala N, Saravanakumar A, Mohanraj S, Sandhiya K, Sesathiri V, "Preliminary Phytochemical Screening and in Vitro Anti-Urolithiatic Activity of Methanol Extract on Leaves of Artocarpus Heterophyllus Lam", Volume 15 Issue 4, April 2026, International Journal of Science and Research (IJSR), Pages: 1427-1440, https://www.ijsr.net/getabstract.php?paperid=SR26309104608, DOI: https://dx.dx.doi.org/10.21275/SR26309104608