Downloads: 2
New Innovation and Idea | Cancer Science | Volume 15 Issue 3, March 2026 | Pages: 848 - 852 | Georgia
AminoTriComplex: Preclinical and Clinical Evidence for a Multi-Component Phytochemical Formulation Targeting Oxidative Stress, Mitochondrial Function, and Cancer-Related Pathways
Abstract: AminoTriComplex (ATC, also referred to as AminoSineTriComplex) is a multi-component phytochemical formulation in which epigallocatechin gallate (EGCG), resveratrol, and berberine are recurrently emphasized as key mechanistic constituents across the available literature. This narrative translational review summarizes preclinical and clinical evidence regarding its potential effects on oxidative stress, mitochondrial function, inflammatory signaling, and cancer-related pathways. In a CCl4-induced oxidative stress rat model, ATC was associated with lower lipid peroxidation, restoration of antioxidant enzyme activity, and improved mitochondrial respiration. In carcinogen-induced rat tumor models, ATC-related reports described modulation of inflammatory, metabolic, and tumor-associated biomarkers. A prospective controlled study in 266 patients with advanced, refractory triple-negative breast cancer receiving metronomic cyclophosphamide and propranolol with or without ATC reported higher objective response rate and longer progression-free survival in the ATC arm. A randomized, double-blind, placebo-controlled study in metastatic colorectal cancer has also been reported, but the current evidence remains limited to an early single-study experience. Overall, the available findings suggest multi-targeted biological activity and possible adjunctive oncological benefit; however, interpretation is constrained by limited independent replication, incomplete methodological reporting, variation in formulation description across reports, and the need for larger randomized studies with overall survival, quality-of-life, pharmacokinetic, and long-term safety endpoints.
Keywords: AminoTriComplex; EGCG; resveratrol; berberine; oxidative stress; mitochondrial protection; triple-negative breast cancer; metastatic colorectal cancer; polypharmacology; metronomic therapy; translational oncology; nanodelivery systems
How to Cite?: Alexandre Tavartkiladze, Russel J. Reiter, Levan Tavartkiladze, Pati Revazishvili, "AminoTriComplex: Preclinical and Clinical Evidence for a Multi-Component Phytochemical Formulation Targeting Oxidative Stress, Mitochondrial Function, and Cancer-Related Pathways", Volume 15 Issue 3, March 2026, International Journal of Science and Research (IJSR), Pages: 848-852, https://www.ijsr.net/getabstract.php?paperid=SR26302015636, DOI: https://dx.dx.doi.org/10.21275/SR26302015636