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Research Paper | Pharmacy | Volume 15 Issue 2, February 2026 | Pages: 1632 - 1637 | India
A Novel UV Spectrophotometric Approach Using Absorbance Correction for Concurrent Quantification of Meloxicam and Rizatriptan Benzoate
Abstract: A novel and highly accurate and cost-effective method for determining the concentrations of the two medications in solution by means of their UV absorbances correction was developed and validated based on the distinctively different UV properties of Meloxicam and Rizatriptan Benzoate. Although the spectra of absorbance for each of the two compounds overlapped, the developed method overcame the overlap (interference) by making use of a unique way to quantify each compound without the need for either separation or isolation. Validation of the proposed method, as per the ICH guidelines (linearity, limit of detection, limit of quantification, precision and accuracy) has successfully been accomplished with the use of methanol as the solvent for all of the studies performed. The calibration graphs for both Meloxicam (2-12 ?g/ml) and Rizatriptan Benzoate (2-12 ?g/ml) show significant linear regressions with all coefficients of determination greater than 0.9900. The recovery rates of 98-102% for both compounds correspond to the accurate quantification of both compounds. Precision studies indicated an %RSD value of
Keywords: Meloxicam, Rizatriptan Benzoate, UV Spectrophotometry, Absorbance Correction, Validation
How to Cite?: Harsh K. Patel, Satish A. Patel, "A Novel UV Spectrophotometric Approach Using Absorbance Correction for Concurrent Quantification of Meloxicam and Rizatriptan Benzoate", Volume 15 Issue 2, February 2026, International Journal of Science and Research (IJSR), Pages: 1632-1637, https://www.ijsr.net/getabstract.php?paperid=SR26225121833, DOI: https://dx.doi.org/10.21275/SR26225121833