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Analysis Study Research Paper | Medical Microbiology | Volume 15 Issue 2, February 2026 | Pages: 1451 - 1453 | India
Comparison of Efficacy of Nitrofurontoin and Ciprofloxacin in Urinary Tract Infections Due to Escherichia Coli
Abstract: Background: Urinary tract infections (UTIs) impose a global health challenge contributing to a significant number of morbidity and mortality. Also, increasing trend Antimicrobial resistance (AMR) is a thing of great concern. This study is aimed at evidence based empirical guidelines in cases of UTI due to infection by Escherichia coli. Since more than 80% isolates were E.coli in this region we aimed at this particular species. Objective: To compare the efficacy of Nitrofurontoin and Ciprofloxacin in cases of urinary tract infections due to Escherichia coli. Place And Duration: This is a retrospective observational analysis and the study was conducted in Srinivas Institute of Medical Sciences and Research Centre, Mukka, Suratkal, Mangalore, in the Department of Microbiology from May 2025 to December 2025. Materials and Methods: A total of 1200 patients with Urinary tract infections were selected for the study. Clean catch mid-stream samples were collected from adult patients with aseptic precautions. Bacterial flora were isolated by standard microbiological methods and antimicrobial susceptibility testing was done by Kirby Bauer?s disc diffusion method. A Chi-square test was performed to compare the sensitivity of Escherichia coli isolates to Nitrofurantoin and Ciprofloxacin. Sensitivity to Nitrofurantoin (89.1%) was significantly higher than Ciprofloxacin (71.7%). Results: A total of 1200 samples were analysed of which 870 cases were sterile. 330 samples were culture positive of which 276 samples showed the growth of Escherichia coli (83.6%), 32 samples yielded Klebsiella pneumoniae (9.7%) and 22 samples showed the growth of other organisms like Enterococci (4.8 % ) and Staphylococci (1.9 %). Only the Escherichia coli isolates were considered for this study as more than 80% cases yielded this organism in pure culture and were tested for the drug sensitivity testing against Nitrofurontoin and Ciprofloxacin using Kirby Bauer?s method. From the total of 276 isolates 246 isolates were sensitive to Nitrofurontoin (89.1%) and 198 were found to be sensitive to Ciprofloxacin (71.7 %) and 158 isolates (57.2%) were sensitive to both Nitrofurontoin and Ciprofloxacin. In this study, of the total 276 cultures 69 belonged to male patients, 207 belonged to females making evident that females are more susceptible to UTI than males. Conclusion: 1) Nitrofurontoin and Ciprofloxacin can be used for Urinary tract infection cases in empirical treatment. 2) Compared to Ciprofloxacin drug, Nitrofurontoin was found to be more better a drug.
Keywords: Urinary tract infections, Escherichia coli, Nitrofurantoin, Ciprofloxacin, Antimicrobial resistance
How to Cite?: Dr. Shailaja Amur, Dr. Harshika, Dr. Pavanchand Attavar, "Comparison of Efficacy of Nitrofurontoin and Ciprofloxacin in Urinary Tract Infections Due to Escherichia Coli", Volume 15 Issue 2, February 2026, International Journal of Science and Research (IJSR), Pages: 1451-1453, https://www.ijsr.net/getabstract.php?paperid=SR26223123553, DOI: https://dx.dx.doi.org/10.21275/SR26223123553