Downloads: 2
Case Studies | Health and Medical Sciences | Volume 15 Issue 2, February 2026 | Pages: 746 - 750 | India
Clinicopathological Study of Acute Appendicitis with Special Reference to the Role of WBC Count, C-Reactive Protein (CRP), Ultrasonography and Alvarado Score in Diagnosis
Abstract: Background: Acute appendicitis is one of the most frequently encountered surgical emergencies across all age groups. Despite advances in diagnostic modalities, the condition continues to pose diagnostic challenges due to variable clinical presentation, leading to negative appendectomies and delayed intervention. Methods: This prospective observational study was conducted in the Department of General Surgery, Hi-Tech Medical College and Hospital, Bhubaneswar, from July 2024 to December 2025. A total of 140 patients presenting with clinical suspicion of acute appendicitis were evaluated using detailed clinical assessment, white blood cell count, C-reactive protein (CRP), ultrasonography (USG), and Alvarado scoring. Operative findings and histopathological examination were used as the reference standard. Results: Young adults constituted the majority of cases. Elevated inflammatory markers, higher Alvarado scores (≥7), and positive ultrasonographic findings showed strong correlation with histopathologically confirmed appendicitis. The combined diagnostic approach significantly improved diagnostic accuracy. Conclusion: Integration of clinical evaluation with laboratory markers, Alvarado scoring, and ultrasonography enhances diagnostic accuracy and reduces negative appendectomy rates.
Keywords: Acute appendicitis, Alvarado score, Ultrasonography, Inflammatory markers, Diagnostic accuracy
How to Cite?: Dr. Shivam Labana, Dr. Debashis Nanda, Dr. Ashoak Acharya, "Clinicopathological Study of Acute Appendicitis with Special Reference to the Role of WBC Count, C-Reactive Protein (CRP), Ultrasonography and Alvarado Score in Diagnosis", Volume 15 Issue 2, February 2026, International Journal of Science and Research (IJSR), Pages: 746-750, https://www.ijsr.net/getabstract.php?paperid=SR26212110006, DOI: https://dx.dx.doi.org/10.21275/SR26212110006