Comprehensive Bioinformatics Analysis of PREX2 Gene Alterations and Expression Patterns in Prostate Adenocarcinoma

Rupal Salwankar, Archana Moon, Amit Taksande, Rupal Ramteke, Tuba Khan, Mohd Vashid Ansari

Abstract: Prostate cancer is one of the most common cancers affecting men around the world. Understanding the genes that drive its growth is essential for finding better ways to diagnose and treat the disease. One such gene, PREX2 regulates cell growth and migration via PI3K/Akt and Rac1 signaling pathways. However, its role in prostate cancer has not been well studied. In this work, a bioinformatics-based approach was explored to understand the role and behaviour of PREX2 in prostate adenocarcinoma. Analysis of large cancer databases, including TCGA and GEO, showed that PREX2 is significantly more active in prostate cancer tissues than in normal samples. Mutations identified in the RhoGEF and PH domains of PREX2, which regulate Rac1 activation and PI3K/Akt signaling, suggest structural alterations that could enhance oncogenic signaling in prostate cancer. PREX2 was also found to be strongly linked with other genes that help cancer cells migrate and invade, such as DDR2 and ROCK2. All of these findings suggest that PREX2 may act as an oncogenic driver in prostate cancer and could serve as a potential biomarker or therapeutic target.

Keywords: PREX2, prostate adenocarcinoma, gene expression, PI3K/Akt signaling, bioinformatics

How to Cite?: Rupal Salwankar, Archana Moon, Amit Taksande, Rupal Ramteke, Tuba Khan, Mohd Vashid Ansari, "Comprehensive Bioinformatics Analysis of PREX2 Gene Alterations and Expression Patterns in Prostate Adenocarcinoma", Volume 15 Issue 1, January 2026, International Journal of Science and Research (IJSR), Pages: 1201-1211, https://www.ijsr.net/getabstract.php?paperid=SR26119180139, DOI: https://dx.doi.org/10.21275/SR26119180139