An Experimental Evaluation of the Tyrosinase-Inhibiting Properties of Talinum triangulare and Physalis Angulata Extracts for Use as Adjuvants in Melanoma Prevention

Marcia Cristina Campos de Oliveira, Mariana de Abreu Soares

Abstract: Melanoma is a common cancer in the Western world, with increasing incidence rates. Sun exposure is widely regarded as the primary risk factor for melanoma. The prognosis for patients with malignant melanoma varies significantly between countries, but public awareness campaigns promoting early detection have led to a substantial reduction in mortality rates. However, current therapies for melanoma are often hampered by melanin-mediated resistance, reducing their overall effectiveness. Suppressing tyrosinase activity and reducing melanogenesis using tyrosinase inhibitors is a promising strategy for sensitizing melanoma cells and enhancing the efficacy of adjuvant therapy. This experimental study investigates the tyrosinase inhibitory activity of extracts from Talinum triangulare and Physalis angulata, two plant species known for their medicinal properties. In vitro assays were used to test several extracts and fractions for their ability to reduce tyrosinase activity, which is a key enzyme involved in melanin synthesis. The methanolic-aqueous extract of T. triangulare demonstrated complete inhibition at the maximum tested concentration of 5.0 mg/mL and an IC?? value of 1.8 mg/mL. Aqueous extracts obtained by decoction also exhibited consistent inhibitory effects. P. angulata showed moderate inhibition; however, purification resulted in fractions with improved IC?? values. These results suggest that both plants, especially T. triangulare, may have therapeutic potential in adjuvant melanoma treatments by reducing melanin-mediated drug resistance.

Keywords: Tyrosinase inhibition, melanoma, Talinum triangulare, Physalis angulata, bioactive plant extracts

How to Cite?: Marcia Cristina Campos de Oliveira, Mariana de Abreu Soares, "An Experimental Evaluation of the Tyrosinase-Inhibiting Properties of Talinum triangulare and Physalis Angulata Extracts for Use as Adjuvants in Melanoma Prevention", Volume 15 Issue 1, January 2026, International Journal of Science and Research (IJSR), Pages: 780-784, https://www.ijsr.net/getabstract.php?paperid=SR26110002834, DOI: https://dx.doi.org/10.21275/SR26110002834