Respiratory Adverse Drug Reaction Profile at a Rural Tertiary Care Hospital: A Five-Year Retrospective Study
Abstract: Introduction: Respiratory adverse Drug Reactions (ADRs) are important safety concerns that require timely recognition and reporting. Objective: To characterize respiratory ADRs reported at Pravara Rural Hospital, Loni, with respect to patient demographics, clinical manifestations and suspected causative drugs. Methods: A descriptive retrospective study analyzed 208 respiratory ADR reports submitted between December 2020 and December 2025. Data were summarized using descriptive statistics and expressed as frequencies and percentages. Results: Males accounted for 112 reports (53.8%) and females for 96 (46.2%). Patients aged 60-80 years constituted 46% of cases. Rebound nasal congestion was the most frequently reported reaction (81; 38.9%), followed by dry cough (54; 26.0%), dysphonia (45; 21.6%), and dyspnoea (28; 13.5%). Rebound congestion was primarily associated with xylometazoline and oxymetazoline. Angiotensin-converting enzyme inhibitors were chiefly associated with dry cough, inhaled corticosteroids with dysphonia, and ACE inhibitors, beta-blockers, and non-steroidal anti-inflammatory drugs with dyspnoea. Conclusion: The observed respiratory ADRs showed consistent drug-specific associations, supporting causality assessment under the Pharmacovigilance Programme of India (PvPI).
Keywords: Respiratory adverse drug reactions, pharmacovigilance, rhinitis, cough, dyspnoea
How to Cite?: Dr. Archana Abhay Patil, Dr. Palak Agrawal, Dr. Rahul R. Kunkulol, "Respiratory Adverse Drug Reaction Profile at a Rural Tertiary Care Hospital: A Five-Year Retrospective Study", Volume 15 Issue 10, October 2026, International Journal of Science and Research (IJSR), Pages: 1238-1240, https://www.ijsr.net/getabstract.php?paperid=SR261019085819, DOI: https://dx.doi.org/10.21275/SR261019085819