A Study of Cognitive Function in Untreated Sub Clinical Hypothyroidism in Elderly
Abstract: Introduction: Subclinical hypothyroidism is prevalent in elderly reaching up to 30% of total population. Various studies yielded discrepant findings regarding cognitive alteration in subclinical hypothyroidism. The present study aimed to look for cognitive dysfunction in elderly subjects with untreated subclinical hypothyroidism and compare it with cognitive function of elderly euthyroid subjects as it has therapeutic implication. Methods: This case control study included 51 cases with subclinical hypothyroidism and 51 controls with euthyroid status and was subjected to history, biochemical tests and cognitive function assessment. Mini Mental State Examination (MMSE), Digital Clock Drawing Test (DCDT), Frontal assessment battery (FAB) and Time taken to complete trail making test (TMT) were used for assessment of cognitive function. Software SPSS version 22 has been used for the statistical analysis. Results: Significantly higher number of subjects in subclinical hypothyroid patients showed lower MMSE and FAB score, poor performance in TMT, and poorly drawn DCDT in comparison to euthyroid subjects. TSH and MMSE, as well as TSH and FAB showed significant negative corelation. Conclusion: Prevalence of cognitive impairment was significantly higher in subclinical hypothyroidism in comparison to euthyroid subjects in our study along with negative correlation of TSH with cognitive function.
Keywords: Subclinical hypothyroidism, neurological involvement, cognitive dysfunction
How to Cite?: Dr. Joydeep Ghosh, Dr Sarmishtha Mukhopadhyay, Dr. Bhaskar Ghosh, "A Study of Cognitive Function in Untreated Sub Clinical Hypothyroidism in Elderly", Volume 15 Issue 10, October 2026, International Journal of Science and Research (IJSR), Pages: 1023-1027, https://www.ijsr.net/getabstract.php?paperid=SR261015154433, DOI: https://dx.doi.org/10.21275/SR261015154433