Stem Cell Therapy Without the Stem Cells: Additional Support for Therapeutic Application of Platelet Lysates
Abstract: Platelet lysates supply platelet-derived biological signals without administering viable stem cells. This AI-assisted narrative investigation evaluates additional support for the Drake-Hicks hypothesis through research using ChatGPT and Google Gemini, comparison of their outputs, and verification of original publications. The findings encompass product characterization, experimental neurological applications, human wound healing, and ocular surface treatment. Studies demonstrate biological activity without transplanted stem cells, although preparations, delivery routes, and evidentiary strength differ. A small double-blind diabetic foot ulcer study reported healing in nine of ten lysate recipients compared with none of nine platelet-poor plasma recipients by day 84. A larger open-label study of topical umbilical cord blood lysate gel also reported greater complete healing than control dressings. Ocular investigations provide additional support for local applications, including treatment of tissue manifestations in patients with an autoimmune condition. Experimental processing studies show that functional activity and procoagulant characteristics depend on preparation methods. The evidence supports platelet-derived preparations as therapeutic candidates without establishing equivalence to cellular therapies or intravenous effectiveness for systemic autoimmune disease. Platelet lysates merit investigation as therapeutic products in their own right, with the strongest verified human support in the local applications examined here.
Keywords: platelet lysate; regenerative medicine; cell-free therapy; diabetic foot ulcer; ocular surface
How to Cite?: Phuc D. Do, "Stem Cell Therapy Without the Stem Cells: Additional Support for Therapeutic Application of Platelet Lysates", Volume 15 Issue 10, October 2026, International Journal of Science and Research (IJSR), Pages: 611-618, https://www.ijsr.net/getabstract.php?paperid=SR261008035919, DOI: https://dx.doi.org/10.21275/SR261008035919