The Effect of Nocturnal Nasal Continuous Positive Airway Pressure Therapy on Obstructive Sleep Apnoea-Hypopnoea Syndrome and Brain Natriuretic Peptide-Biomarker for Cardiac Failure

Kanodia Madhu, Kanodia Vivek, Talwar Deepak

Abstract: Background: Obstructive sleep apnoea hypopnoea syndrome (OSAHS) is characterized by repetitive apnoea and hypopnoea, excessive daytime sleepiness, fatigue, raised levels of brain natriuretic peptide (BNP) and higher incidence of cardiovascular morbidity. Objectives: Evaluation of nocturnal nasal continuous positive airway pressure (nCPAP) therapy and BNP levels in OSAHS. Materials and Methods: Twenty OSAHS patients-ten with and ten without overt heart failure (HF)-underwent baseline clinical assessment, overnight polysomnography and blood BNP assay. HF patients were treated medically for two weeks followed by nCPAP therapy for two weeks; non-HF patients were only given 4-week nCPAP therapy. BNP assay was repeated after medical and nCPAP therapies. Results: nCPAP therapy produced statistically significant improvement of symptoms and improved Epworth sleepiness score in both groups of patients. Baseline median BNP values were significantly raised in both, more so in the HF group (160.92 vs 678.55 pg / ml; normal ? 100pg / ml). In the HF group, while medical treatment did not produce a significant decrease in BNP values, nCPAP therapy produced a statistically significant decrease in BNP values. In the non-HF group also, nCPAP therapy produced statistically significant decrease in BNP values. Post-nCPAP therapy, BNP values were normalized in both groups (HF-93.49; non-HF-58.02 pg / ml; p- <0.05). Conclusions: OSAHS patients may have cardiac involvement even in absence of overt HF. They should be treated with nocturnal nCPAP for 4-6 hr daily. with monitoring of BNP levels.

Keywords: Obstructive sleep apnoea, OSA, brain natriuretic peptide, CPAP

How to Cite?: Kanodia Madhu, Kanodia Vivek, Talwar Deepak, "The Effect of Nocturnal Nasal Continuous Positive Airway Pressure Therapy on Obstructive Sleep Apnoea-Hypopnoea Syndrome and Brain Natriuretic Peptide-Biomarker for Cardiac Failure", Volume 14 Issue 9, September 2025, International Journal of Science and Research (IJSR), Pages: 1548-1553, https://www.ijsr.net/getabstract.php?paperid=SR25929122435, DOI: https://dx.doi.org/10.21275/SR25929122435