Click Synthesis and Spectral Characterization of a 1,2,3-Triazole Conjugated Pyrrole-2,5-dione Scaffold

Uday Mishra, Saheban Khan, Vinod Kumar, Nitesh Kumar, Ram Kumar

Abstract: This study presents the synthesis and characterization of a novel 1,2,3-triazole conjugated pyrrole-2,5-dione compound via copper-catalyzed azide-alkyne cycloaddition (click chemistry). The synthetic route involves the reaction of benzyl azide with a pyrrole-2,5-dione-derived alkyne under mild conditions, yielding the target compound in excellent purity and yield (92 percent). The final product was comprehensively characterized using FT-IR, ¹H-NMR, ¹³C-NMR, and high-resolution mass spectrometry, confirming its structural integrity. The reported methodology contributes to the development of bioactive heterocyclic scaffolds with potential pharmaceutical relevance.

Keywords: Click chemistry, 1,2,3-triazole, pyrrole-2,5-dione, copper catalysis, heterocyclic scaffold

How to Cite?: Uday Mishra, Saheban Khan, Vinod Kumar, Nitesh Kumar, Ram Kumar, "Click Synthesis and Spectral Characterization of a 1,2,3-Triazole Conjugated Pyrrole-2,5-dione Scaffold", Volume 14 Issue 9, September 2025, International Journal of Science and Research (IJSR), Pages: 1209-1213, https://www.ijsr.net/getabstract.php?paperid=SR25923100202, DOI: https://dx.doi.org/10.21275/SR25923100202